Kyma is a visual programming language for sound design used by musicians, researchers, and sound designers. From the wikipedia article:
The first version of Kyma, which computed digital audio samples on a Macintosh 512K was written in the Smalltalk programming language in 1986 by Carla Scaletti in Champaign, Illinois. In May 1987, Scaletti had partitioned Kyma into graphics and sound generation engines and ported the sound generation code to a digital signal processor called the Platypus. When the University of Illinois at Urbana-Champaign eliminated the funding for the PLATO laboratory in 1989, Scaletti and Hebel formed Symbolic Sound Corporation in order to continue developing Kyma and digital audio signal processing hardware.
Now Kyma 7 is out as this video demonstrates and you can look at it for some included Smalltalk scripting. This is also explained in this PDF.
There is also an intro video on Youtube.